Morphometric and morphological evaluation of temporozygomatic suture anatomy in dry adult human skulls.

This study aims to evaluate the position, morphometric, and morphological features of the temporozygomatic suture (TZS) located on the zygomatic arch (ZA) in dry adult human skulls. Thirty-two crania were evaluated. Measurements for the TZS were carried out using the ImageJ software. Morphometric measurements were carried out bilaterally in 23 crania and unilaterally in 9 crania (right: 4, left: 5). A total of 55 TZSs were analyzed. Localization of the TZS was determined according to the reference landmarks on the ZA. Morphologic features of the TZS evaluated in terms of "joint shape type" and "suture margin pattern". Descriptive statistics of the morphometric and morphologic variables were calculated. A statistically significant difference between the right and left sides was observed for the localization of the TZS (p < 0.05). TZS is located more anteriorly on the left side than the right side. Based on the "joint shape type", four types of TZS were observed: Type 1 (angular) (34.55%), Type 2 (curvy) (34.55%), Type 3 (oblique) (14.55%), Type 4 (horizontal) (16.36%). Based on the "suture margin pattern", five types of TZS were observed: Type A (linear) (12.73%), Type B (denticulate) (34.55%), Type C (serrated) (23.64%), Type D (mixt) (21.82%), Type E (fused) (7.27%). No significant association between the type and lateralization was found for both morphologic classifications. To the best of our knowledge, this is the first published report regarding the localization and morphologic classification of the TZS in adult human crania. Considering the TZS with its morphometric and morphological features may contribute to clinical or forensic medical evaluations.

Assessment of the opinions and experiences of anatomy educators regarding the distance anatomy education in medical facilities under the effect of COVID-19 in Turkey.

PURPOSE: Aim of this research is to assess the perceptions and views of the anatomy lecturers (educators) of the medical faculties in Turkey on undergraduate distance anatomy education during the COVID-19. METHODS: Anatomy educators nationwide were invited to the online questionnaire developed by the authors. Ninety-one anatomy educators participated in the questionnaire. Views of the participants were evaluated by Likert-type questions and open-ended questions. Distance anatomy education experiences of the participants between March and July 2020 were evaluated. RESULTS: Participants found face-to-face education more beneficial than distance education courses conducted with video recordings. They also reported that they agreed synchronous lessons were more beneficial than asynchronous lessons. They agreed that time management was a positive result. However, they were concerned about the adverse effects of the interruption of formal anatomy education regarding quality. The experience of distance anatomy education applied during the COVID-19 pandemic has revealed the demand for distance theoretical anatomy education supported by video recordings and face-to-face practical anatomy education methods (blended) for the post-pandemic period. CONCLUSION: There is much research focusing on the students regarding the effects of the COVID-19 pandemic on anatomy education. The experiences and the suggestions of the anatomy educators are also important. The findings of the current research have revealed the positive approach to distance theoretical anatomy education and face-to-face practical anatomy education methods (blended) for the post-pandemic period.

Evaluation of views and perceptions of the medical faculty students about distance anatomy education during the COVID-19 pandemic.

PURPOSE: This study aimed to investigate the students' opinions about the distance anatomy education given in our faculty at the COVID-19 pandemic and present our department's experiences. METHODS: An online questionnaire designed for medical faculty students. The questionnaire was applied to 355 volunteer medical faculty students. The questionnaire consisted of demographics, five-point Likert items, and open-ended questions. The questionnaire was applied between August and September 2020. Distance anatomy education activities were evaluated during March and July 2020. RESULTS: Results showed face-to-face theoretical anatomy education was found to be more effective than distance anatomy education conducted with recorded lecture videos. Even though the positive aspects of distance anatomy education stand out in topics, such as time management, it has been stated that cadaver and laboratory education has been disrupted. Most of the students agreed that they spent more time on supplementary resources during distance anatomy education. CONCLUSION: The COVID-19 pandemic has provided an unexpected experimental environment. The demand for a blended method, which consists of distance (supported by video recordings) theoretical anatomy education and face-to-face practical anatomy education for the post-pandemic period comes to the fore. Distance anatomy education brings some problems with it due to its nature, and it is essential to seek unique solutions to them. Evaluating the perceptions of the parties will play an essential role in solving the problems of distance anatomy education and in the formation of future anatomy education styles.

The practical examination types (spot test and slide test) of gross anatomy course in faculty of medicine: a simultaneous evaluation of the aspect of student success.

PURPOSE: This study aimed to compare the students' scores of the spot (spotter/classical/traditional/tag/ring/bell-ringer) test (3D environment) performed in the laboratory with the slide test (gross anatomy images) (2D environment) in the class. The observation of our department regarding both types for practical examination was reported, in terms of exam marks of the students. Both are preferred as the practical examination types for gross anatomy course our in medical faculty. METHODS: The 29 blocks' scores in 5 years (2013/2014-2017/2018) belonging to first- and second-year medical students' spot tests and slide tests are evaluated retrospectively and statistically compared. Correlations of the spot tests and the slide tests, besides the correlations between theoretical examinations and the practical examination types, are calculated. RESULTS: Spot test scores were significantly higher (p < 0.05) in nine blocks, while slide test scores were higher significantly (p < 0.05) in fourteen. There was no statistically significant difference between the practical examination types (spot/slide) in six blocks. There were correlations between the spot test and the slide test in all blocks (p < 0.001). CONCLUSION: It is considered that the spot test reflects the success/ability in a 3D environment, while the slide test reflects it in the 2D environment. In conclusion, neither of these two types of examinations stands out absolutely. Both types of examinations have their own features in areas, such as assessment power, applicability, and effect on success.

Assessment of awareness, knowledge and attitudes about the importance of cadaver and cadaver donation: report of Izmir, Turkey / Evaluación de la conciencia, el conocimiento y las actitudes sobre la importancia del cadáver y la donación de cadáveres: informe de Izmir, Turquía

The aim of this study was to evaluate the awareness, knowledge level and attitudes of the community in I˙zmir/ Turkey about cadaver donation in medical education. A cross-sectional study was carried out. Randomly chosen 245 participants answered twenty items in the questionnaire providing information about their demographics (5 items), awareness and knowledge (10 items), and attitudes (5 items) about body donation. The questionnaire was applied face-to-face. Descriptive statistics presented. Student T test and One-Way ANOVA test were used for statistical analysis. 123 (50.2 %) participants were male and 159 (64.9 %) were between 30 to 59 years old. 185 (75.5 %) respondents knew what the word "cadaver" means. When asked where they would apply if they decided to donate their body, 104 (42.4 %) of the participants gave the answer "state hospital". The mean score of awareness and knowledge about importance of cadaver and body donation (AWKL-Score) was 0.41±0.24 (min:0.00, max:0.90). AWKL-Score was statistically higher in the youngest (18-29 y) and oldest (>60 y) compared to the other age groups (F:4.115; p:0.007). AWKL-Score increased as the level of education increased. The highest AWKL-Score was at post-graduate level (Level 7,8) (F:22.997; p<0.001). The AWKL-Score was higher in public employees and students compared to other occupational groups (F:5.930; p<0,001). The answers to the questionnaire were important indicators of how much society needs to be informed regarding body donation.

El objetivo de este estudio fue evaluar el nivel de conciencia, conocimiento y las actitudes de la comunidad en Izmir / Turquía sobre la donación de cadáveres en la educación médica. Se realizó un estudio transversal de 245 participantes elegidos al azar, que respondieron veinte ítems en el cuestionario proporcionando información sobre su demografía (5 ítems), conciencia y conocimiento (10 ítems) y actitudes (5 ítems) sobre la donación de cuerpos. El cuestionario fue administrado directamente en persona; la prueba T de Student y la prueba ANOVA de una vía se utilizaron para el análisis estadístico. De los participantes 123 (50,2 %) eran hombres y 159 (64,9 %) tenían entre 30 y 59 años. 185 (75,5 %) encuestados sabían lo que significa la palabra "cadáver". Cuando se les preguntó dónde se registrarían, en caso de decidir donar su cuerpo, 104 (42,4 %) de los participantes respondieron "hospital estatal". La puntuación media de conciencia y conocimiento sobre la importancia del cadáver y la donación de cuerpos (puntuación AWKL) fue de 0,41 ± 0,24 (mínimo: 0,00, máximo: 0,90). Estadísticamente el puntaje AWKL fue más alto en los más jóvenes (18-29 años) y mayores (> 60 años) en comparación con los otros grupos etarios (F: 4,115; p: 0.007). AWKL-Score aumentó a medida que aumentó el nivel de educación. El puntaje AWKL más alto fue en el nivel de posgrado (Nivel 7,8) (F: 22,997; p <0,001). El puntaje AWKL fue mayor en empleados públicos y estudiantes en comparación con otros grupos ocupacionales (F: 5,930; p <0,001). Las respuestas al cuestionario fueron indicadores importantes de cuánto necesita la sociedad estar informada sobre la donación de cuerpos.

The morphometry, localization, and shape types of the fovea capitis femoris, and their relationship with the femoral head parameters.

PURPOSE: The aim of this study was to investigate the morphometric properties of the fovea capitis femoris (FCF) and its localization on the femoral head, the shape types, and the relationship with the femoral head parameters. METHODS: This study was performed on 146 dry femora. The morphological and morphometric properties were evaluated on dry bones and digital images of these bones. Some of the FCF and femoral head parameters were measured with a caliper on dry bones while others were measured using ImageJ software on digital images. RESULTS: The most common localization type was the Type 2 localization and the shape type was the oval type. The FCF sizes [except depth of the FCF (DFCF)] were found to be smaller in the Type 1 localization. The femoral neck shaft angle (NSA) was found to be greater in the triangular type than the round (or circular) type on the left side and in all cases. The vertical diameter of the femoral head (FHD-V), the anteroposterior diameter of the femoral head (FHD-AP), and the area of the femoral head (AREAHOF) values were greater in the triangular types than in the oval types in all cases. There was no relationship between the localization types and the shape types of the FCF. CONCLUSION: Results showed that the morphometric properties, localization, and shape types of the FCF were related to some femoral head parameters. It is thought that our findings contributed to orthopedic and radiological applications and anthropological sciences.

The investigation of the carrying angle of the elbow in fetal period.

PURPOSE: The aim of our study was to determine the carrying angle in human fetuses and to identify variations in carrying angle by gender, fetal age and elbow side in fetal period. METHODS: This study was carried out on 20 dead human fetuses (13 males, 7 females) fixed with formaldehyde, aged between 10-35 weeks of gestation, without external anomalies. Ages of the fetuses were determined according to the general growth parameters. First, the fetus arms were positioned in 180° extension and the forearms were placed in supination. Then the midpoints of the caput humeri, the elbow joint and the wrist were determined. The photographs were taken from the anterior aspect. The distances between the reference points and carrying angles were measured using ImageJ program in the photographs. RESULTS: The mean ± SD values of carrying angle were 14.18 ± 5.52 and 8.21 ± 4.82 degrees in males and in females, respectively. Although there was no difference between right and left sides within both genders, there was a significant difference between genders (p < 0.05). Gestational age and fetal carrying angle showed a medium negative correlation at the right arm and a weak negative correlation at the left arm. CONCLUSION: The existence of a significant difference between fetal carrying angles belong to different genders suggested that the sexual dimorphism of carrying angles may be starting at the early intrauterine period. The carrying angle should be explained with the studies performed in larger series in the prenatal and postnatal periods.

Radiological investigation and clinical evaluation of the morphometric development of the forearm in human fetuses / Investigación radiológica y evaluación clínica del desarrollo morfométrico del antebrazo en fetos humanos

Fetal period of time during which the fetus grows rapidly and the organs are formed. The prenatal and postnatal analyses of the fetal structure provide information as to fetal growth, growth retardation, gestational age and congenital malformations. The development of the skeletal system during the intrauterine period takes place in an orderly manner as it also does in other systems. It was aimed that the morphometric development of the forearm in human fetuses during the period between 20-40 gestational weeks be radiologically investigated and that its clinical importance be evaluated, as well. A total of 100 fetal forearms (50 fetuses: 23 male, 27 female), the ages of which varied between 20-40 gestational weeks, without having any external pathology or anomaly were incorporated into the study. The fetuses were separated into groups according to weeks, trimesters and months. After the general external measurements of the fetuses had been performed, the mammographies and forearm radiographies of the fetuses were shot in the way that the forearms would remain in a prone position. Morphometric measurements pertaining to forearm structures were taken from the forearm radiographies that were shot with the help of a digital compass. Later on, the morphometric measurements in question were statistically evaluated. The mean values and the standard deviations of the measured parameters were determined according to gestational weeks, trimesters and months. There was a significant correlation between the measured parameters and the gestational age (p<0.001). In the comparison of the measured parameters between trimesters and months, it was observed that there was a statistically significant difference between the groups (p<0.05). Separately, it was also determined that there was no statistically significant difference in the comparison of the parameters, which was made between genders and right-left forearms (p>0.05). As for the results obtained in our study, we are of the opinion that the data obtained during this study period will be beneficial for the involved clinicians, such as those in charge of gynecology, radiology, forensic medicine and perinatology, in terms of evaluating the clinical studies related to the morphometric development of the forearm throughout the fetal period, in determining the fetal age and sex, and also in determining the pathologies and variations regarding the development of fetal skeletal system.

El período fetal es el tiempo en el cual el feto crece rápidamente y se forman los órganos. Los análisis prenatal y postnatal de la estructura fetal proporcionan información sobre el crecimiento fetal, el retraso de crecimiento, la edad gestacional y las malformaciones congénitas. El desarrollo del sistema esquelético, como también el de otros sistemas durante el período intrauterino, avanza de manera ordenada. Se investigó radiológicamente el desarrollo morfométrico del antebrazo en fetos humanos durante el período comprendido entre 20-40 semanas gestacionales y se evaluó su importancia clínica. Un total de 100 antebrazos fetales (50 fetos: 23 de sexo masculino, 27 de sexo femenino), cuya edad varió entre 20-40 semanas de gestación, sin patología externa o anomalía, fueron incluidos en el estudio. Los fetos fueron separados en grupos de semanas, trimestres y meses. Después de realizar las mediciones externas generales de los fetos, las mamografías y las radiografías fueron realizadas de tal manera que los antebrazos permanecieran en pronación. Las radiografías de las medidas morfométricas correspondientes a las estructuras del antebrazo se tomaron con apoyo de una compás digital; posteriormente, las medidas fueron tratadas estadísticamente. Los valores medios y las desviaciones estándar de los parámetros medidos se determinaron de acuerdo con las semanas de gestación, los trimestres y los meses. Hubo una correlación significativa entre los parámetros medidos y la edad gestacional (p <0,001). En la comparación de los parámetros medidos entre los trimestres y los meses, se observó una diferencia estadísticamente significativa entre los grupos (p <0,05). Se determinó también que no hubo diferencias estadísticamente significativas en la comparación de los parámetros, que se realizó entre los sexos y los antebrazos derecho-izquierdo (p> 0,05). En cuanto a los resultados de nuestro estudio, los datos obtenidos durante este período de estudio serán beneficiosos para los clínicos, como también para profesionales de las áreas de ginecología, radiología, medicina forense y perinatología, en la evaluación de estudios clínicos relacionados con el desarrollo morfométrico del antebrazo durante todo el período fetal, determinación de la edad y el sexo fetal, así como en la determinación de variaciones en el desarrollo del sistema esquelético fetal.

Cephalometric investigation of craniomaxillofacial structures during the prenatal period: a cadaver study.

INTRODUCTION: We aimed to investigate the morphometric development of the cranial base and its related structures, and their growth rate changes from the ninth gestational week to full term in a large group of human fetuses. METHODS: We selected 203 (109 male, 94 female) fetuses between 9 and 40 weeks of gestation and without any external anomalies. From each fetus, standard lateral and posteroanterior cephalometric images were taken using a dental digital panoramic and cephalometric x-ray machine. Fourteen linear and 9 angular parameters were measured. RESULTS: The cranial base angle showed a statistically significant increase between the groups from only the second to the third trimester periods. The sagittal translation of the maxilla increased during the prenatal period, whereas the mandibular sagittal relation grew at a steady rate. The vertical plane angles of the maxilla and the mandible did not show any significant changes. The maxillary length to mandibular length ratio remained stable. CONCLUSIONS: The cranial base angle increased, especially in the second through the third trimesters. The maxilla and the mandible demonstrated different growth patterns in the sagittal direction. The findings of this study could be a guide for interpreting the relationships among the craniofacial structures.

Morphometric evaluation of craniofacial and alveolar arch structures in anencephalic human fetuses: a cadaveric study.

Objective : The aim of the present study was to compare the morphometrics of the craniofacial and alveolar arch structures of anencephalic fetuses with those of normal human fetuses without anencephaly or any other anomaly. Design : Original article. Methods : Standard lateral and posteroanterior cephalometric radiographs of 23 anencephalic and 33 normal human fetuses aged between 21 and 40 weeks of gestation were compared. These fetuses were divided into three periods based on gestational age, and vertical, sagittal, transverse, and angular measurements were taken in the cranial base and facial regions. Moreover, intraoral measurements from the maxillary and mandibular arches were also made to determine the width and depth. Results : N-S and S-Ba lengths and the N-S-Ba angle, measured on lateral cephalometric radiographs, were statistically smaller in anencephalic fetuses (p < .05). The S-N-ANS, S-N-Pg, and ANS-N-Pg angles and the Go-Me length were significantly greater in anencephalic fetuses (p < .05). Maxillary length, ramus length, and anterior facial heights were similar in both groups. On posteroanterior radiographs, all parameters except bigonial distance were found to be smaller in the anencephalic fetuses (p < .05). Maxillary alveolar width was small among anencephalic fetuses in all three periods; whereas, the mandibular alveolar width was narrow only in the third period. Conclusion : Cranial and facial structures were affected morphometrically to various degrees in anencephalic cases. The most significant alterations in anencephalic cases were related to measurements in the transverse direction. This indicated that cephalic tissue influenced not only the cranial base but also all facial structures.

An investigation into the morphometric developments of the maxillary and mandibular arches during the fetal period.

OBJECTIVE: The objective of this study was to determine the developments, morphometric features, and shapes of the maxillary and mandibular arches during the prenatal period in a large series of fetal material. METHODS: The study was carried out on 225 human fetuses aged between 8 and 40 weeks of gestation. General, extraoral, and intraoral parameters were taken from each fetus. The width and depth measurements and the shapes of the maxillary and mandibular arches were achieved using the casts obtained. The arches were categorized according to the shapes of the anterior and posterior regions of the arches. RESULTS: Palatal and mandibular indices did not change during the prenatal period. Maxillary arch measurements were greater than the mandibular measurements. Moreover, width measurements of both arches were greater than the depth measurements during fetal life. We found that the frequencies of triangular maxillary and mandibular arches were highest in the first and second trimesters; whereas, the square model became more frequent in the third trimester and at full term. Classification of the arches according to their posterior regions showed that the tips of the arches shifted medially toward the term. There were significant correlations between width and depth parameters of the arches and extraoral parameters. CONCLUSION: Data obtained in the study would be useful for clinicians by presenting an objective scale related to the prenatal period as well as being helpful in assessing the development of this region, identifying the anomalies and pathologies, and assisting treatment.

The impact of prefertilization chronic mild stress on postnatal morphometric development.

OBJECTIVE: The aim of the present study was to examine the effects of chronic mild stress (CMS) induced before the fertilization on gestational maternal weight, length of gestation, and postnatal morphometric development. MATERIAL AND METHOD: Study is carried out on 18 Wistar albino rats; six females in the stress group, six females in the control group, and six males to be used for mating. CMS was induced in rats of the stress group for 4 weeks, followed by a post-CMS waiting period of 5-weeks. Rats were left for mating at the end of the post-CMS period. Weight gain in pregnant rats was monitored and length of gestation and litter size were recorded in the stress and control groups. Growth parameters of pups pertaining to the body, cranium, thorax, and limbs were measured until week 11. FINDINGS: Weight gained by pregnant rats in the stress group was less than the control group. Increases in mean morphometric parameters from day 0 to week 11 in the stress group were less than the control group (p < 0.05). Furthermore, when developmental parameters at weeks 7, 9, and 11 were compared between genders, females in the stress group were found more affected than males (p < 0.05). CONCLUSION: CMS sustained before fertilization has a negative effect on gestational maternal weight and postnatal morphometric development of pups, more prominently in females.

Size and location of the kidneys during the fetal period.

PURPOSE: The aim of this study was to determine the morphometric development and location of the kidneys during the fetal period. METHODS: Three hundred and forty-four fetal kidneys, obtained from 172 human fetuses and aged between 9 and 40 weeks, were used in this study. Fetuses were divided into four groups according to the gestational weeks: first trimester, second trimester, third trimester, and full-term gestation. First, the anterior abdominal wall was dissected. Topographic localization of the kidneys in the abdominal cavity was then assessed. The distance between the inferior pole of the kidney and iliac crest was measured. The vertebral levels of the superior and the inferior poles and relations to ribs of the kidneys were determined. The distances between hilum of the kidneys and inferior vena cava, abdominal aorta, and midline of the vertebral column were determined. The dimensions (width, length, and thickness), weight, and volume of kidneys were measured. RESULTS: The results showed that the distance between the inferior poles of the kidneys and the iliac crest increases with gestational age. The vertebral levels of the superior and inferior poles of the kidneys increased during the fetal period. The level of the left kidney was higher than the level of the right kidney in the fetal period. The posterior surface relations to the ribs showed certain ascendance during gestation, corresponding to vertebral levels. However, fetal kidneys do not reach the same level as adults at full term. The kidneys move farther apart from the midline of the body during the fetal period. The dimensions, weight, and volume of the kidneys increased with gestational age during the fetal period. The ratio between kidney weights and fetal body weights were determined, and we observed that the ratio decreased during the fetal period. There were no sex or laterality differences in any parameter. CONCLUSIONS: The morphometric parameters and the location of the fetal kidneys were determined by the present study. This will also contribute to imaging of fetal kidneys and detection of kidney abnormalities in the intrauterine period. We hope that the present results can provide some useful findings for radiological (ultrasound and MR) studies.

Morphometry of the gallbladder during the fetal period.

PURPOSE: In this study, our objective was to investigate the development of the gallbladder, its morphological structure and relationship with the adjacent organs during the fetal period. MATERIALS AND METHODS: A total of 118 human fetuses (60 males, 58 females) between 9 and 40 weeks of gestation without any external anomaly or pathology were included. They were divided into four groups according the gestational age: I (9-12 weeks), II (13-25 weeks), III (26-37 weeks) and IV (term, 38-40 weeks). The location of gallbladder on the visceral surface of liver has been identified. The gallbladders have been classified into four different types. Width and length of the gallbladder were measured and the relationship between fundus of gallbladder and inferior margin of the liver was noted. FINDINGS: The gallbladder was located on the visceral surface of liver in all cases during the fetal period. There were no differences between males and females by means of length and width. There was a statistically significant relationship between the size of gallbladder and the gestational age (P < 0.001). There was also a significant difference in the distribution of gallbladder types among the groups during the fetal period. The fundus of gallbladder was under the transverse plane passing from the part of inferior margin of the liver near the gallbladder in 14% of the cases. RESULTS: We concluded that there could be different types of gallbladders during the fetal period. We believe that the data collected in our study may contribute to the evaluation of the gallbladder development during the intrauterine period.

The development of fetal pylorus during the fetal period.

OBJECTIVE: The objective of this study was to explore the localization of the pylorus, its macroscopic and microscopic development and relationship with neighboring structures. MATERIALS AND METHODS: The study is carried out on 160 human fetuses aged between 9 and 40 weeks of gestation. Abdomen was divided into four quadrants by horizontal and vertical planes passing through the umbilicus. Topographical localization of the pylorus in reference to these quadrants and its distance were determined. Pylorus was divided into pre-pyloric, pyloric, and post-pyloric regions. Starting from the pre-pyloric end, serial sections spanning whole pyloric part were obtained. Wall thickness, the thickness of the muscular coat were measured under light microscope using sections stained with hematoxylin eosin. Sections with the thickest muscular coat were considered as the region where pyloric sphincter was. FINDINGS: Pylorus was located in the right upper quadrant, on the median plane and in the left upper quadrant. There was a significant relation between the thickness of the muscular coat in the stomach, duodenum and the pyloric region and gestational age. In the region of the pyloric sphincter, the rate of increase in the thickness of the muscular coat was higher in the first and the first half of the second trimesters than term fetuses. CONCLUSION: We believe that data obtained in the present study will contribute to the assessment of development of the pyloric region in intra-uterine cases.

Development of spleen during the fetal period.

OBJECTIVE: This study was aimed to determine the location and development of the spleen in the human fetuses. MATERIALS AND METHODS: The study was carried on 141 dead human fetuses aged between 9 and 40 weeks with no marked pathology and anomaly in the years 2002-2003. The location of spleen with the neighboring structures, the existence of accessory spleens, notches on the borders, fissures on the surfaces, major ligaments and the shape of spleen and its hilum were established. The spleen was completely observed intraperitoneally (except at the hilum), in the left hypochondrium throughout the fetal period. The length, width, thickness, weight, volume, and the hilum dimensions of spleen were measured. RESULTS: The dimensions, weight, and volume of the spleen were increased with the gestational age, and positive significant correlations were determined (P < 0.001). There was no difference between sexes in all parameters (P > 0.05). The length of the spleen has ranged between 3.1 and 35.6 mm, between 9 weeks old and 40-week-old fetuses, respectively. One or more accessory spleens have been found in 14% of cases. CONCLUSION: The measurements and location of the spleen according to the gestational age were determined by the present study. The expression of morphometric parameters of the spleen at different gestational ages can be used in determination of pathologies of the spleen and may also contribute to future studies on this issue.

Size and location of the fetal diaphragm during the fetal period in human fetuses.

AIM: The aim of this study was to determine the development and the size and localization of the diaphragm during the fetal period in human fetuses. MATERIALS AND METHODS: One hundred and eighty-four diaphragm obtained from human fetuses aged between 9 and 40 weeks of gestation was used in this study. The localization of the diaphragm with respect to abdominal cavity and the level of costodiaphragmatic recess with respect to the ribs were determined. The dimensions (height, width, and depth) of the diaphragm were measured. The diameter and localization of apertures on the diaphragm were determined. RESULTS: During the fetal period, the costodiaphragmatic recess was most commonly located at the level of the 9th rib. Means and standard deviations of the all parameters with respect to gestational weeks and months were calculated. No significant differences were observed between sexes for any of the parameters (P > 0.05). All parameters were increasing with age during fetal period. There was significant correlation between gestational age and all parameters (P < 0.001). The localizations of the diaphragmatic apertures did not change throughout the fetal period and aortic hiatus and oesophageal hiatus were most frequently situated to the left of the median plane. CONCLUSION: New data are derived for human fetuses to evaluate diaphragmatic development. Data acquired in this study are believed to contribute to studies of obstetrics, perinatology, forensic medicine and fetal pathology on fetal development of the diaphragm, and diagnosis of its anomalies, pathologies and variations.

The development of stomach during the fetal period.

The objective of this study was to explore the fetal development of the stomach, its morphology and relationship with neighboring structures. The study is carried out in 2003 using 160 human embryos and fetuses (81 males and 79 females) aged between 9 and 40 weeks of gestation. None of the cases had any external pathology or anomaly. Its topographical localization and relationship with surrounding structures were revealed with anatomical dissections. Width and height of the stomach, lengths of the greater and lesser curvatures, the angle between horizontal and vertical axes of the stomach and types of stomach were established. During the fetal life stomach was most commonly located above the transverse axis passing through the umbilicus, in left and right hypochondrium (81%). There were significant differences among trimester groups with respect to the localization of the stomach in the quadrants (P < 0.001). There were no significant sex differences in parameters. After the second trimester, the height of the stomach increased more than the width of the stomach and anterior abdominal height. The angle of stomach decreased from 100 degrees to 50 degrees throughout the fetal period. During the fetal period, wide angles stomach was more common in the first(f) and second trimesters while acute-angled stomach was more common in the third trimester and term fetuses. Diagnosis and treatment of fetal anomalies and pathologies of the stomach requires knowledge of fetal anatomy of the stomach. Data acquired in this study are believed to contribute to the studies of obstetrics, perinatology, forensic medicine and fetal pathology on fetal development of the stomach, and diagnosis and treatment of its anomalies, pathologies, and variations.

Determination of dimensions and angles of mandible in the fetal period.

The aim of the present study was to determine the dimensions of the mandible during the fetal period, the relationship between the growth rates of the angle of the mandible and the dimensions of the mandible. Furthermore the angle of union of the two halves of the body of the mandible on the horizontal mandibular plane, which was not described elsewhere, is explored in this study. One hundred and sixty-one human fetuses (83 males and 78 females) without any cranio-facial or mandibular asymmetry, external pathology or anomaly and aged between 9 and 40 weeks of gestation were used in the study. Cases were stratified into four groups according to their developmental ages, that is, first trimester, second trimester, third trimester, and term fetuses. Cranio-facial parameters in addition to bi-condylar, bi-gonial, bi-mental tubercular, condyle-gonion, gonion-mental tubercle, condyle-mental tubercle, gonion-pogonion distances were measured. The degree of the angle of the mandible, angle of union of the two halves of the body of the mandible and sagittal length of the base of the mandible were calculated. The means of the parameters with respect to gestational weeks and groups were computed. While there were no sex differences in any of the parameters (P>0.05) there were very significant relationships between gestational age and parameters (P<0.001). The mean degree of the angle of the mandible during the fetal period was 122+/-8 degrees . The mean alpha angle of the base of the mandible was 65+/-8 degrees . None of these angles varied significantly throughout the fetal period. Height of the ramus of the mandible increased more than the length of the body of the mandible and bi-gonial distance in the first and second trimesters while in the third trimester and term period they increased at the same rate. Comparisons of groups for the ratio of the transverse to the sagittal lengths of the mandible revealed significant differences between first and second trimesters with term group (P<0.05). Accordingly, bi-gonial distance of the mandible increased more during the third trimester and term time than the first and second trimesters, compared with the sagittal length of the mandible. The morphometric features and architectural changes observed in the mandible do not totally occur during the fetal period but continue later in childhood and adulthood.

Lithium-induced lung toxicity in rats: the effect of caffeic acid phenethyl ester (CAPE).

AIMS: We aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) on lithium (Li)-induced lung toxicity. METHODS: Twenty-two adult male Wistar albino rats weighing between 280 and 300 g were used. The rats were randomly divided into three groups: control, Li and Li+CAPE groups. Li and CAPE were co-administered intraperitoneally twice daily for 4 weeks. Control rats were given 0.9% NaCl during the same period. All the rats were allowed to feed ad libitum until midnight after they had received the proposed treatment. RESULTS: In the Li group, peribronchial and intraparenchymal lymphocyte and macrophage infiltration were observed. Atypical type II pneumocytes, alveolar destruction and emphysematous changes were also detected. Lymphocyte and macrophage infiltration was significantly decreased in the Li+CAPE group compared with the Li group. Alveolar destruction, emphysematous changes and intraparenchymal mononuclear cell infiltration were also recovered to a level close to the control group. Malondialdehyde (MDA) levels were increased in the Li group compared with the control group. CAPE administration decreased the MDA levels in the Li+CAPE group. CONCLUSIONS: CAPE was found to associate with histopathological changes recovery in the lungs and oxidative stress due to Li treatment.